The contribution of inherited non‐genetic factors to complex diseases is of great current interest. The ways in which mothers and fathers can affect their offspring's health clearly differ as a result of the intimate interactions between mother and offspring during pre‐ and postnatal life. There is, however, potential for some overlap in mechanisms, particularly epigenetic mechanisms. A small number of epidemiological studies and animal models have investigated the non‐genetic contribution of the parents to offspring health. Discovering new mechanisms of disease (...) inheritance is technically difficult, especially in genetically, socially and environmentally heterogeneous human populations. Therefore, rigorous experimental design, appropriate sample numbers and the use of high‐throughput technologies are necessary to provide convincing evidence. Based on recent examples from the literature, here we propose several ways to improve human studies that aim to identify the underlying mechanisms of transgenerational inheritance of metabolic disease. (shrink)

Christopher Maloney offers an explanation of the fundamental nature of thought. He posits the idea that thinking involves the processing of mental representations that take the form of sentences in a covert language encoded in the mind. The theory relies upon traditional categories of psychology, including such notions as belief and desire. It also draws upon and thus inherits some of the problems of artificial intelligence which it attempts to answer, including what bestows meaning or content upon a (...) thought and what distinguishes genuine from simulated thought. (shrink)

The Representational Theory of the Mind allows for psychological explanations couched in terms of the contents of propositional attitudes. Propositional attitudes themselves are taken to be relations to mental representations. These representations (partially) determine the contents of the attitudes in which they figure. Thus, Representationalism owes an explanation of the contents of mental representations. This essay constitutes an atomistic theory of the content of formally or syntactically simple mental representation, proposing that the content of such a representation is determined by (...) the intersection of the representation's correlational and control properties. The theory is distinguished from standard information-based accounts of mental content in allowing that the relevant correlations be contingent while insisting on an efferent aspect to mental content. The theory on offer allows for a natural explanation of misrepresentation, finds a niche for the notion of narrow content, welcomes radical first person fallibility with respect to questions of content, admits of mental ambiguity and recognizes that the future of a psychological agent is a factor in determining the content of the agent's present psychological states. (shrink)

An account of the contents of the propositional attitudes is fundamental to the success of the cognitive sciences if, as seems correct, the cognitive sciences do presuppose propositional attitudes. Fodor has recently pointed the way towards a naturalistic explication of mental content in his Psychosemantics (1987). Fodor's theory is a version of the causal theory of meaning and thus inherits many of its virtues, including its intrinsic plausibility. Nevertheless, the proposal may suffer from two deficiencies: (1) It seems not to (...) provide an adequate explanation of misrepresentation. (2) It may also fail, as a species of empiricism, to provide a correct explication of the content of observational concepts and those non-observational concepts whose meaning is to be traced to their causal connections with observational concepts. (shrink)

Metaphors are expressions in artificial, contrived, alien languages, and we understand metaphors by constructing translation schemes linking our natural, literal languages to these theoretically contrived metaphorical languages. The relation between a literal natural language and a metaphorical contrived language is like the relationship between a natively known language and a system of subsequently acquired languages etymologically emerging from that basic natural language. This model for understanding metaphorically contrived language is kin to the familiar model explaining how speakers of a language (...) such as Latin may come to decipher a language like Spanish through projecting to Spanish what they know of Latin without the aid of a translation manual. A metaphor is, thus, seen as a sentence in a nonnatural language, itself derived from and at least partially translatable with the natural, literal language of the metaphor's author or audience. (shrink)

Current computational psychology, especially as described by Fodor (1975, 1980, 1981), Pylyshyn (1980), and Stich (1983), is both a bold, promising program for cognitive science and an alternative to naturalistic psychology (Putnam 1975). Whereas naturalistic psychology depends on the general scientific framework to fix the meanings of general terms and, hence, the content of thoughts utilizing or expressed in those terms, computational cognitive theory banishes semantical considerations in psychological investigations, embracing methodological, not ontological, solipsism. I intend to argue that computational (...) psychology cannot individuate thoughts as it promises. For, semantics is fundamental in fixing an important subset of the computational relations that, according to the computational theory, are supposed both to obtain among thoughts and, thereby, to determine their identity conditions. If what I contend is correct, then contrary to what its advocates maintain, computational psychology is not preferable to naturalistic psychology as a research strategy in cognitive science. (shrink)

The Representational Theory of the Mind arises with the recognition that thoughts have contents carried by mental representations. For Abelard to think, for example, that Pegasus is winged is for Abelard to be related to a MENTAL REPRESENTATION whose content is that Pegasus is winged. Now, there are different kinds of representations: pictures, maps, models, and words ‐ to name only some. Exactly what sort of REPRESENTATION is mental representation? (see imagery; connectionism.) Sententialism distinguishes itself as a version of rep‐resentationalism (...) by positing that mental representations are themselves linguistic expressions within a ‘language of thought’ (FODOR, 1975, 1987; Field, 1978; Maloney, 1989). While some sententialists conjecture that the language of thought is just the thinker's spoken language internalized (Harman, 1982), others identify the language of thought with Mentalese, an unarticulated, internal language in which the computations supposedly definitive of cognition occur. Sententialism is certainly a bold and provocative thesis, and so we turn to the reasons that might be offered on its behalf. (shrink)

This is Putnam at his critical best; he is once again directing the shape of the philosophy of mind for years to come. Putnam scouts with dissatisfaction the prevailing functionalist/computationalist theory of mental states, a view he himself originated more than thirty years ago. Here he despairs of any reductionist theory of mental states, denying that there are naturalistically specifiable natures comprehending mental states of the same kind, although he continues to allow that token mental states may be emergent from (...) and supervenient upon computational states. Putnam is not, then, an eliminativist. Mentalistic eliminativism implies semantic eliminativism generally and, thus, the rejection of both reference and truth, amounting absurdly--by Putnam's lights--to the loss of logic. (shrink)

This fascinating study explores the difficulties faced by modern Westerners in their search for a meaningful life. It sheds light on this enduring cultural dilemma through a close reading of four popular film and television narratives: Pixar's animated feature film, Toy Story; Christopher Nolan's Batman Begins and The Dark Knight; the television romantic comedy, Sex and the City; and, finally, the mobster drama, The Sopranos. The readings are guided by a number of inter-related questions. First, in what ways do (...) these popular stories speak to the modern West's meaning dilemma? What do they have to say about contemporary culture, and its capacity to illuminate the fundamental human? What are the core problems faced by the central characters and how are they resolved? Finally, and perhaps most importantly, do the four stories that come into focus suggest hope or despair in the modern West's search for meaning? (shrink)

I argue that despite criticism from some disability rights organizations, aid in dying is morally permissible. First, I suggest that disability-related concerns can be classified as emerging from one of two kinds of harm: person affecting, and personhood affecting. Second, I examine whether person affecting harm has occurred within those jurisdictions that have legalized aid in dying. I conclude that despite suggestions to the contrary, there is no evidence to demonstrate that people with disabilities have been adversely impacted by legalized (...) medical aid in dying. Third, I entertain these same arguments as a matter of principle and conclude the principled objections should not give us reason for concern. Fourth, I explore whether we have evidence to suggest the presence of increased personhood affecting harm where aid in dying is permissible. I suggest, through a focus on disability support services, that no evidence of social attitudes that diminish the moral worth of disabled people is present. Fifth, I examine whether we ought to have a principled concern with personhood affecting harm emerging from medical aid in dying. I conclude that to the contrary, to deny people with disabilities access to aid in dying constitutes a morally egregious form of personhood affecting harm. (shrink)

Amyloid-beta peptide plaque in the brain is the primary diagnostic criterion of Alzheimer's disease . The physiological role of Abeta are poorly understood. We have previously determined an Abeta interacting domain in the promoters of AD-associated genes . This AbetaID interacts in a DNA sequence-specific manner with Abeta. We now demonstrate novel Abeta activity as a possible transcription factor. Herein, we detected Abeta-chromatin interaction in cell culture by ChIP assay. We observed that human neuroblastoma cells treated with FITC conjugated Abeta1-40 (...) localized Abeta to the nucleus in the presence of H2O2-mediated oxidative stress. Furthermore, primary rat fetal cerebrocortical cultures were transfected with APP and BACE1 promoter-luciferase fusions, and rat PC12 cultures were transfected with polymorphic APP promoter-CAT fusion clones. Transfected cells were treated with different Abeta peptides and/or H2O2. Abeta treatment of cell cultures produced a DNA sequence-specific response in cells transfected with polymorphic APP clones. Our results suggest the Abeta peptide may regulate its own production through feedback on its precursor protein and BACE1, leading to amyloidogenesis in AD. (shrink)

There is a growing consensus among philosophers that hope is a moral virtue: the virtuously hopeful person experiences the right amount of hope for the right things. This moralization of hope presents us with a puzzle. The historical consensus is that hope is a passion and hope is a theological virtue, not a moral virtue. Thomas Aquinas, the philosopher who wrote most extensively on hope, offers an explanation for why hope is not a moral virtue. The aim of this paper (...) is argue that Aquinas is right in thinking that hope is not a moral virtue.1. (shrink)

Giubilini and Minerva argue that the permissibility of abortion entails the permissibility of infanticide. Proponents of what we refer to as the Birth Strategy claim that there is a morally significant difference brought about at birth that accounts for our strong intuition that killing newborns is morally impermissible. We argue that strategy does not account for the moral intuition that late-term, non-therapeutic abortions are morally impermissible. Advocates of the Birth Strategy must either judge non-therapeutic abortions as impermissible in the later (...) stages of pregnancy or conclude that they are permissible on the basis of premises that are far less intuitively plausible than the opposite conclusion and its supporting premises. (shrink)

This paper offers a new argument against raising and killing sentient non-human animals for food. It is immoral to non-lethally impair sentient non-human animals for pleasure, and since raising and killing sentient animals for gustatory pleasure impairs them to a much greater degree, it also is wrong. This is because of the impairment principle: if it is immoral to impair an organism to some degree, then, ceteris paribus, it is immoral to impair it to a higher degree. This argument is (...) structurally analogous to Perry Hendricks’s impairment argument for the immorality of abortion. However, the argument is more defensible applied to the raising and killing of sentient nonhuman animals for food because of the sentience of the non-human animals involved. I explain how the argument is distinct from other pro-vegan, pro-vegetarian arguments. (shrink)

Would the virtuous person eat animals? According to some ethicists, the answer is a resounding no, at least for the virtuous person living in an affluent society. The virtuous person cares about animal suffering, and so, she will not contribute to practices that involve animal suffering when she can easily adopt a strict plant-based diet. The virtuous person is temperate, and temperance involves not indulging in unhealthy diets, which include diets that incorporate animals. Moreover, it is unjust for an animal (...) to be killed for food when this is unnecessary. By contrast, I argue that the virtuous person in an affluent society would eat animals, at least sometimes. I explain how the very virtues thought to motivate “virtuous modest veganism”—compassion, temperance, and justice—motivate the virtuous person to consume some animals. (shrink)

Accounts of practical deliberation tend to overlook any possible role for hope. I offer an argument showing that hope sets the ends of our practical deliberations and is thereby necessary for practical deliberation. It is because I hope to summit the mountain by midday that I deliberate about how to do so. Absent this particular hope, I could not deliberate about how to summit the mountain by midday.

If non-human animals have high moral status, then we commit a grave moral error by eating them. Eating animals is thus morally risky, while many agree that it is morally permissible to not eat animals. According to some philosophers, then, non-animal ethicists should err on the side of caution and refrain from eating animals. I argue that this precautionary argument assumes a false dichotomy of dietary options: a diet that includes farm-raised animals or a diet that does not include animals (...) of any kind. There is a third dietary option, namely, a diet of plants and non-traditional animal protein, and there is evidence that such a diet results in the least amount of harm to animals. It follows therefore that moral uncertainty does not support the adoption of a vegetarian diet. (shrink)

In ‘Dilemma for Appeals to the Moral Significance of Birth’, we argued that a dilemma is faced by those who believe that birth is the event at which infanticide is ruled out. Those who reject the moral permissibility of infanticide by appeal to the moral significance of birth must either accept the moral permissibility of a late-term abortion for a non-therapeutic reason or not. If they accept it, they need to account for the strong intuition that her decision is wrong (...) as well as deny the underlying normative principle that killing a viable fetus requires good reason, and not wanting to care for the child when the child could be easily placed for adoption is not a good enough reason to abort. If they reject the moral permissibility of the late-term abortion, they need to explain why her decision is wrong. Doing so, however, will undermine their own project of denying infanticide by appeal to birth. Walter Veit argues that the dilemma relies too much on intuition and does not live up to biological continuity. We explain why his criticisms are unconvincing. (shrink)

Abstract Jeffrey Koperski claims in Zygon (2008) that critics of Intelligent Design engage in fallacious ad hominem attacks on ID proponents and that this is a “bad way” to engage them. I show that Koperski has made several errors in his evaluation of the ID critics. He does not distinguish legitimate, relevant ad hominem arguments from fallacious ad hominem attacks. He conflates (or equates) the logical use of valid with the colloquial use of valid. Moreover, Koperski doesn't take seriously the (...) legitimate concerns of the ID critics, and in doing so, commits the straw man fallacy. In the end, I show that no one disagrees with the criticism of improper use of fallacies as methods of evaluation. But what constitutes proper, relevant evaluation of the ID theorists and their motivation is a matter of dispute. And sometimes attacking a person as a method of evaluation is justified, and thus is not fallacious. The definition of ad hominem arguments as either a “good way” or a “bad way” rests on justification, which I argue ID opponents have. The basis for these good objections relies on the motivation many Christians have to share their faith with non-Christians, which they call the “great commission.”. (shrink)

Hope is important in Thomas Aquinas’s account of the emotions: it is one of the four primary emotions and the first of the irascible emotions. Yet his account of hope as a movement of the sensory appetite toward a future possible good that is arduous to attain appears to be overly restrictive, for people often hope for things that are not cognized as arduous. This paper examines Aquinas’s reasons for limiting hope to arduous goods.

Prabhpal Singh has defended a relational account of the difference in moral status between fetuses and newborns. Newborns stand in the parent-child relation while fetuses do not, and standing in the parent-child relationship brings with it higher moral status for newborns. Orphans pose a problem for this account because they do not stand in a parent-child relationship. I argue that Singh has not satisfactorily responded to the problem.

Although populism is an ideologically fluid political vehicle, it is not one that is intrinsically anti-business. Indeed, different varieties of populist parties may encourage business activity for utilitarian ends, but with their own ideas on what businesses should be doing. This reality implies that initiatives not related to national greatness or priorities as defined by the populist leadership may be viewed as redundant. Key among such initiatives would be corporate social responsibility (CSR). In a populist environment, it is possible that (...) firms may divert resources away from broad-based CSR under pressure from populist governments. This article explores the relationship between populist governance and CSR with an econometric examination of over a thousand firms in 13 countries under both pro- and anti-business populist governments at varying times from 2012 to 2020. Using dynamic panel data methods, we find strong evidence that firms substitute away significantly from CSR under populism. This effect grows significantly larger under anti-business populists. (shrink)

Recent discussions surrounding the conceptualising of disability has resulted in a stalemate between British sociologists and philosophers. The stagnation of theorizing that has occurred threatens not only academic pursuits and the advancement of theoretical interpretations within the Disability Studies community, but also how we educate and advocate politically, legally, and socially. More pointedly, many activists and theorists in the UK appear to believe the British social model is the only effective means of understanding and advocating on behalf of people with (...) disabilities. This model, largely reliant upon materialist research traditions, contends that disability is a form of social oppression and hence, is a phenomenon that should be conceptualised in social terms. Individual properties such as impairments are disregarded as they are viewed to be unimportant in the analysis of the social causes of disability. Concurrently, many bioethicists and philosophers have embraced what Tom Shakespeare has classified as an ‘Interactional Approach’ to disability—that “the experience of a disabled person results from the relationship between factors intrinsic to the individual, and the extrinsic factors arising from the wider context in which she finds herself”. I intend to demonstrate that the benefits of the British social model are now outweighed by its burdens. I suggest, as Jerome Bickenbach has, that while it may be somewhat churlish to critique the social model in light of its political success, taken literally, it implies that people with disabilities require no additional health resources by virtue of their impairments. Despite the eloquent arguments that have preceded me by interactional theorists, none have been accepted as evidence of fallacious reasoning by British social model theorists. This article is an attempt to clarify why it is that the types of arguments British social model theorists have been offering are misguided. I suggest that the British social model, unlike an interactional approach, is unable to provide a realistic account of the experience of disability, and subsequently, unable to be properly utilized to ensure justice for people with disabilities. (shrink)

This article explores at least two dominant critiques of assisted dying from a disability rights perspective. In spite of these critiques, I conclude that assisted dying ought to be permissible. I arrive at the conclusion that if we respect and value people with disabilities, we ought to permit assisted dying. I do so in the following manner. First, I examine recent changes in legislation that have occurred since the Royal Society of Canada Expert Panel on End-of-Life Decision-Making report, published in (...) this journal. I suggest that these changes are likely to only strengthen opposition to assisted dying from disability rights activists and people with disabilities. Second, I focus on respect for people with disabilities and in particular, respect for their autonomy and decision-making abilities. Third, I explore the opposition to assisted dying that focuses on risk and the vulnerability of people with disabilities. Here I suggest that this risk ought not to be of special concern. Ultimately, I conclude that upholding respect for the disabled requires the legalization of assisted dying, rather than the denial of access in a misguided effort to protect people with disabilities. (shrink)

This unique interpretation of Alfarabi's thought stresses the ways in which the tenth-century Arab philosopher self-consciously broke the metaphysical tradition that began with Plato. By examining Alfarabi's work as more than an extension or continuation of Greek philosophy, Colmo rethinks what medieval philosophy is and challenges almost universal assumptions about the origins of modernity.

Smajdor’s Reification and Assent in Research Involving Those Who lack Capacity claims, among other things, that ‘adults who cannot give informed consent may nevertheless have the ability to assent and dissent, and that these capacities are morally important in the context of research’.1 More pointedly, she suggests we can rely upon Gillick competence, or that ‘it is worth thinking about why the same trajectory [as children] has not been evident in the context of [adults with impairments of capacity to give (...) informed consent (AWIC)]’.1 I argue that her likening assent in AWIC to assent in children is problematic for at least two related reasons. First, direct comparisons between AWIC and children run the risk of perpetuating or reinforcing infantilising stereotypes against people with disabilities. Second, I argue that people with disabilities are vulnerable in ways that most children are not, and thus, are dissimilar in a morally relevant manner. The infantilising of people with disabilities is quite widely documented and thought to be deeply problematic.2 Not only are people with disabilities often thought to be infantile in regard to particular …. (shrink)

Thomas Aquinas divides the sensory appetite into two powers: the irascible and the concupiscible. The irascible power moves creatures toward arduous goods and away from arduous evils, while the concupiscible power moves creatures toward pleasant goods and away from non-arduous evils. Despite the importance of this distinction, it remains unclear what counts as an arduous good or evil, and why arduousness is the defining feature of the division. The aim of this paper is twofold. First, I argue that an arduous (...) object is one that is difficult and important for the creature. Second, given this proper understanding of arduousness, I highlight the shortcomings of the standard interpretation of Aquinas’s argument for the irascible-concupiscible distinction and suggest an alternative. I argue that Aquinas grounds the distinction in the distinction between useful and pleasant goods. I explain how these distinct goods allow arduousness to be the defining feature of the irascible-concupiscible division. (shrink)

Theory and practice, reason and revelation, ancients and moderns are the key themes running through the eighteen studies of the literature of political philosophy in Reason's Inquisition. Alfarabi is a pivotal figure, but the range is wide, from Plato and Thucydides to Shakespeare and Hobbes, extending to such contemporary figures as Leo Strauss and Eric Voegelin.

The American Journal of Bioethics, Volume 11, Issue 7, Page 53-55, July 2011.

In the quantum-Bayesian approach to quantum foundations, a quantum state is viewed as an expression of an agent’s personalist Bayesian degrees of belief, or probabilities, concerning the results of measurements. These probabilities obey the usual probability rules as required by Dutch-book coherence, but quantum mechanics imposes additional constraints upon them. In this paper, we explore the question of deriving the structure of quantum-state space from a set of assumptions in the spirit of quantum Bayesianism. The starting point is the representation (...) of quantum states induced by a symmetric informationally complete measurement or SIC. In this representation, the Born rule takes the form of a particularly simple modification of the law of total probability. We show how to derive key features of quantum-state space from (i) the requirement that the Born rule arises as a simple modification of the law of total probability and (ii) a limited number of additional assumptions of a strong Bayesian flavor. (shrink)

Societal pressures, accreditation organizations, and licensing agencies are emphasizing the importance of ethics in the engineering curriculum. Traditionally, this subject has been taught using dogma, heuristics, and case study approaches. Most recently a number of organizations have sought to increase the utility of these approaches by utilizing the Internet. Resources from these organizations include on-line courses and tests, videos, and DVDs. While these individual approaches provide a foundation on which to base engineering ethics, they may be limited in developing a (...) student’s ability to identify, analyze, and respond to engineering ethics situations outside of the classroom environment. More effective approaches utilize a combination of these types of approaches. This paper describes the design and development of an internet based interactive Simulator for Engineering Ethics Education. The simulator places students in first person perspective scenarios involving different types of ethical situations. Students must gather data, assess the situation, and make decisions. This requires students to develop their own ability to identify and respond to ethical engineering situations. A limited comparison between the internet based interactive simulator and conventional internet web based instruction indicates a statistically significant improvement of 32% in instructional effectiveness. The simulator is currently being used at the University of Houston to help fulfill ABET requirements. (shrink)

This article suggests that those individuals typically acknowledged as vulnerable during public health crises, such as pandemics, are often-times doubly so. I suggest that individuals can be vulnerable in a person-affecting way as well as in a personhood-affecting way. I suggest that the former notion of vulnerability coincides with many existing accounts of vulnerability and that subsequently, many of the more standard arguments for moral and justice-based obligations to minimize such vulnerability, hold. I also suggest that the latter notion of (...) vulnerability adds another layer of vulnerability to those that we typically view to be at risk. I argue that personhood-vulnerability constitutes a novel interpretation of vulnerability than expands our ideas of the kinds of harm that emerge during public health crises. (shrink)

This essay surveys some of the problems facing theories of public deliberation that are “exclusivist” insofar as they account for good participation in terms of a citizen’s refusal to use certain kinds of reasons. It then argues for a more promising alternative: one that focuses on citizens’ character rather than the content of their reasons. More specifically, it is possible to distinguish good participation from bad by considering the extent to which the citizen possesses and demonstrates the virtue of reasonableness. (...) This virtue-based account avoids the problems facing exclusivism, while still providing a basis for evaluating civic participation. (shrink)